Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults
Abstract Background Paracetamol, either alone or in combination with codeine or dihydrocodeine, is commonly used to treat chronic neuropathic pain. This review sought evidence for efficacy and harm from randomised double-blind studies. Objectives To assess the analgesic efficacy and adverse events of paracetamol with or without codeine or dihydrocodeine for chronic neuropathic pain in adults. […]
Non-steroidal anti-inflammatory drugs for sciatica
Abstract Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently prescribed drugs for the treatment of sciatica. A previous Cochrane review on the efficacy of NSAIDs summarised findings for acute and chronic low back pain (LBP) and sciatica. This is an update of the original review (2008) focusing on people suffering from sciatica. […]
Hydromorphone for cancer pain
Abstract Background Cancer pain is an important and distressing symptom that tends to increase in frequency and intensity as the cancer advances. For people with advanced cancer, the prevalence of pain can be as high as 90%. It has been estimated that 30% to 50% of people with cancer categorise their pain as moderate to […]
Fentanyl for neuropathic pain in adults
Abstract Background Opioid drugs, including fentanyl, are commonly used to treat neuropathic pain, and are considered effective by some professionals. Most reviews have examined all opioids together. This review sought evidence specifically for fentanyl, at any dose, and by any route of administration. Other opioids are considered in separate reviews. Objectives To assess the analgesic […]
Pregabalin for pain in fibromyalgia in adults
Abstract Background This review updates part of an earlier Cochrane review on ‘Pregabalin for acute and chronic pain in adults’ (Moore 2009), and considers only fibromyalgia pain. Antiepileptic drugs have been used in pain management since the 1960s. Pregabalin is an antiepileptic drug also used in management of chronic pain conditions, including fibromyalgia. Pain response […]
Oxycodone for pain in fibromyalgia in adults
Abstract Background This review replaces part of an earlier review that evaluated oxycodone for both neuropathic pain and fibromyalgia, which has now been split into separate reviews for the two conditions. This review will consider pain in fibromyalgia only. Opioid drugs are commonly used to treat fibromyalgia, but they may not be beneficial for people […]
Cannabinoids for fibromyalgia
Abstract Background This review is one of a series on drugs used to treat fibromyalgia. Fibromyalgia is a clinically well-defined chronic condition of unknown aetiology characterised by chronic widespread pain that often co-exists with sleep problems and fatigue affecting approximately 2% of the general population. People often report high disability levels and poor health-related quality […]
Oral non-steroidal anti-inflammatory drugs (single dose) for perineal pain in the early postpartum period
Abstract Background Many women experience perineal pain after childbirth, especially after having sustained perineal trauma. Perineal pain-management strategies are thus an important part of postnatal care. Non-steroidal anti-inflammatory drugs (NSAIDs) are a commonly used type of medication in the management of postpartum pain and their effectiveness and safety should be assessed. Objectives To determine the […]
Antipsychotics for fibromyalgia in adults
Abstract Background This review is one of a series on drugs used to treat fibromyalgia. Fibromyalgia is a clinically well-defined chronic condition of unknown aetiology characterised by chronic widespread pain that often co-exists with sleep problems and fatigue. It affects approximately 2% of the general population. Up to 70% of patients with fibromyalgia meet the […]
Hydromorphone for neuropathic pain in adults
Abstract Background Opioid drugs, including hydromorphone, are commonly used to treat neuropathic pain, and are considered effective by some professionals. Most reviews have examined all opioids together. This review sought evidence specifically for hydromorphone, at any dose, and by any route of administration. Other opioids are considered in separate reviews. This review is part of […]