Tramadol for neuropathic pain in adults
Abstract Background This review is an update of a review of tramadol for neuropathic pain, published in 2006; updating was to bring the review in line with current standards. Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Peripheral neuropathic pain often includes […]
Gabapentin for chronic neuropathic pain and fibromyalgia in adults
Abstract Background Gabapentin is commonly used to treat neuropathic pain (pain due to nerve damage). This review updates a review published in 2014, and previous reviews published in 2011, 2005 and 2000. Objectives To assess the analgesic efficacy and adverse effects of gabapentin in chronic neuropathic pain in adults. Search methods For this update we […]
Morphine for chronic neuropathic pain in adults
Abstract Background Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. Neuropathic pain is a common symptom in […]
Methadone for neuropathic pain in adults
Abstract Background This review replaces an earlier review, “Methadone for chronic non-cancer pain in adults”. This review serves to update the original and includes only studies of neuropathic pain. Methadone belongs to a class of analgesics known as opioids, that are considered the cornerstone of therapy for moderate-to-severe postsurgical pain and pain due to life-threatening […]
Topical analgesics for acute and chronic pain in adults – an overview of Cochrane Reviews
Abstract Background Topical analgesic drugs are used for a variety of painful conditions. Some are acute, typically strains or sprains, tendinopathy, or muscle aches. Others are chronic, typically osteoarthritis of hand or knee, or neuropathic pain. Objectives To provide an overview of the analgesic efficacy and associated adverse events of topical analgesics (primarily nonsteroidal anti-inflammatory […]
Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
Abstract Background Chronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%. For many years, the treatment choice for chronic pain […]
Oral nonsteroidal anti-inflammatory drugs for fibromyalgia in adults
Abstract Background Oral nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of pain in fibromyalgia, despite being considered not to be effective. Objectives To assess the analgesic efficacy, tolerability (drop-out due to adverse events), and safety (serious adverse events) of oral nonsteroidal anti-inflammatory drugs for fibromyalgia in adults. Search methods We searched CENTRAL, […]
Yoga treYoga treatment for chronic non-specific low back painatment for chronic non-specific low back pain
Abstract Background Non-specific low back pain is a common, potentially disabling condition usually treated with self-care and non-prescription medication. For chronic low back pain, current guidelines state that exercise therapy may be beneficial. Yoga is a mind-body exercise sometimes used for non-specific low back pain. Objectives To assess the effects of yoga for treating chronic […]
Stretch for the treatment and prevention of contractures
Abstract Background Contractures are a common complication of neurological and non-neurological conditions, and are characterised by a reduction in joint mobility. Stretch is widely used for the treatment and prevention of contractures. However, it is not clear whether stretch is effective. This review is an update of the original 2010 version of this review. Objectives […]
Gabapentin for fibromyalgia pain in adults
Abstract Background This review replaces part of an earlier review that evaluated gabapentin for both neuropathic pain and fibromyalgia, now split into separate reviews for the two conditions. This review will consider pain in fibromyalgia only. Fibromyalgia is associated with widespread pain lasting longer than three months, and is frequently associated with symptoms such as […]