Topical clonidine for neuropathic pain
Abstract Background Clonidine is a presynaptic alpha‐2‐adrenergic receptor agonist that has been used for many years to treat hypertension and other conditions, including chronic pain. Adverse events associated with systemic use of the drug have limited its application. Topical use of drugs has been gaining interest since the beginning of the century, as it may […]
Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery
Abstract Background Pain following brain surgery can compromise recovery. Several pharmacological interventions have been used to prevent pain after craniotomy; however, there is currently a lack of evidence regarding which interventions are most effective. Objectives The objectives are to assess the effectiveness of pharmacological interventions for prevention of acute postoperative pain in adults undergoing brain […]
Flexibility exercise training for adults with fibromyalgia
Abstract Background Exercise training is commonly recommended for adults with fibromyalgia. We defined flexibility exercise training programs as those involving movements of a joint or a series of joints, through complete range of motion, thus targeting major muscle‐tendon units. This review is one of a series of reviews updating the first review published in 2002. […]
Genetic testing for prevention of severe drug‐induced skin rash
Abstract Background Drug‐induced skin reactions present with a range of clinical symptoms, from mild maculopapular skin rashes to potentially fatal blistering skin rashes — such as Stevens‐Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) — which may result in death. Milder reactions may be troublesome and lead to low drug compliance. The pathogenesis of these […]
Interventions for treating neuropathic pain in people with sickle cell disease
Abstract Background Pain is the hallmark of sickle cell disease (SCD) and it can be severe, frequent and unpredictable. Although nociceptive pain is more common, at times, people with SCD may have neuropathic pain. The latter can occur due to peripheral or central nerve injury. This review is focused on identifying treatment of only painful […]
Interventions for treating neuropathic pain in people with sickle cell disease
Abstract Background Pain is the hallmark of sickle cell disease (SCD) and it can be severe, frequent and unpredictable. Although nociceptive pain is more common, at times, people with SCD may have neuropathic pain. The latter can occur due to peripheral or central nerve injury. This review is focused on identifying treatment of only painful […]
Mixed exercise training for adults with fibromyalgia
Abstract Background Exercise training is commonly recommended for individuals with fibromyalgia. This review is one of a series of reviews about exercise training for fibromyalgia that will replace the review titled “Exercise for treating fibromyalgia syndrome”, which was first published in 2002. Objectives To evaluate the benefits and harms of mixed exercise training protocols that […]
Mixed exercise training for adults with fibromyalgia
Abstract Background Exercise training is commonly recommended for individuals with fibromyalgia. This review is one of a series of reviews about exercise training for fibromyalgia that will replace the review titled “Exercise for treating fibromyalgia syndrome”, which was first published in 2002. Objectives To evaluate the benefits and harms of mixed exercise training protocols that […]
Transcutaneous electrical nerve stimulation (TENS) for chronic pain ‐ an overview of Cochrane Reviews
Abstract Background Chronic pain, considered to be pain lasting more than three months, is a common and often difficult to treat condition that can significantly impact upon function and quality of life. Treatment typically includes pharmacological and non‐pharmacological approaches. Transcutaneous electrical nerve stimulation (TENS) is an adjunct non‐pharmacological treatment commonly recommended by clinicians and often […]
Herbal medicinal products or preparations for neuropathic pain
Abstract Neuropathic pain is a consequence of damage to the central nervous system (CNS), for example, cerebrovascular accident, multiple sclerosis or spinal cord injury, or peripheral nervous system (PNS), for example, painful diabetic neuropathy (PDN), postherpetic neuralgia (PHN), or surgery. Evidence suggests that people suffering from neuropathic pain are likely to seek alternative modes of […]