Ergonomic positioning or equipment for treating carpal tunnel syndrome
Abstract Background Non-surgical treatment, including ergonomic positioning or equipment, are sometimes offered to people experiencing mild to moderate symptoms from carpal tunnel syndrome (CTS). The effectiveness and duration of benefit from ergonomic positioning or equipment interventions for treating CTS are unknown. Objectives To assess the effects of ergonomic positioning or equipment compared with no treatment, […]
Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults
Abstract Background Valproic acid and its sodium salt (sodium valproate) are antiepileptic drugs that are sometimes used to treat chronic neuropathic pain and fibromyalgia, although they are not licensed for this use. Objectives To evaluate the analgesic efficacy and adverse effects of valproic acid and sodium valproate in the management of chronic neuropathic pain and […]
Treatment for idiopathic and hereditary neuralgic amyotrophy (brachial neuritis)
Abstract Background Neuralgic amyotrophy (also know as Parsonage-Turner syndrome or brachial plexus neuritis) is a distinct peripheral nervous system disorder characterised by episodes (attacks) of extreme neuropathic pain and rapid multifocal weakness and atrophy in the upper limbs. Neuralgic amyotrophy has both an idiopathic and hereditary form, with similar clinical symptoms but generally an earlier […]
Immunosuppressive treatment for non-systemic vasculitic neuropathy
Abstract Background Non-systemic vasculitic neuropathy is a rare disabling disease that usually has a subacute onset of progressive or relapsing-remitting sensory or sensorimotor deficits. Asymmetry, pain and weakness are key features. The diagnosis can only be made by exclusion of other causes, the absence of systemic vasculitis or other rheumatic diseases, and the demonstration of […]
Vaccination for preventing postherpetic neuralgia
Abstract Background Herpes zoster virus vaccine was recommended for the prevention of herpes zoster and its sequelae by the Advisory Committee on Immunization Practices (ACIP) in 2006. To date the efficacy and safety of vaccination for preventing the most common complication of zoster, postherpetic neuralgia, has not been systematically reviewed. Objectives To assess the efficacy and safety of vaccination in preventing postherpetic neuralgia. […]
Multidisciplinary care for Guillain-Barré syndrome
Abstract Background Guillain-Barré syndrome is a significant cause of new long-term disability, which is thought to be amenable to multidisciplinary care, but the evidence base for its effectiveness is unclear. Objectives To assess the effectiveness of multidisciplinary care in adults with Guillain-Barré syndrome, especially the types of approaches that are effective (settings, intensity) and the […]
Exercise for people with peripheral neuropathy
Abstract Background Peripheral neuropathies are a wide range of diseases affecting the peripheral nerves. Demyelination or axonal degeneration gives rise to a variety of symptoms including reduced or altered sensation, pain, muscle weakness and fatigue. Secondary disability arises and this may result in adjustments to psychological and social function. Exercise therapy, with a view to […]
Treatment for Fisher syndrome, Bickerstaff’s brainstem encephalitis and related disorders
Abstract Background Fisher syndrome is one of the regional variants of Guillain-Barré syndrome, characterised by impairment of eye movements (ophthalmoplegia), incoordination (ataxia) and loss of tendon reflexes (areflexia). It can occur in more limited forms, and may overlap with Guillain-Barré syndrome. A further variant is associated with upper motor neuron signs and disturbance of consciousness […]
Surgical versus non-surgical treatment for carpal tunnel syndrome
Abstract Background Carpal tunnel syndrome results from entrapment of the median nerve in the wrist. Common symptoms are tingling, numbness, and pain in the hand that may radiate to the forearm or shoulder. Most symptomatic cases are treated non-surgically. Objectives The objective is to compare the efficacy of surgical treatment of carpal tunnel syndrome with […]
Decompressive surgery of lower limbs for symmetrical diabetic peripheral neuropathy
Abstract Background Symmetrical peripheral neuropathy is a common complication of diabetic neuropathy. No treatments are known to be effective for progressive pain and sensory loss associated with diabetic neuropathy. Alternative effective treatment strategies have been sought. Objectives To systematically review the evidence from randomized controlled trials concerning the role of decompressive surgery of lower limbs […]