Topical clonidine for neuropathic pain
Abstract Background Clonidine is a presynaptic alpha‐2‐adrenergic receptor agonist that has been used for many years to treat hypertension and other conditions, including chronic pain. Adverse events associated with systemic use of the drug have limited its application. Topical use of drugs has been gaining interest since the beginning of the century, as it may […]
Immunoglobulin for multifocal motor neuropathy
Abstract Background Multifocal motor neuropathy (MMN) is a rare, probably immune‐mediated disorder characterised by slowly progressive, asymmetric, distal weakness of one or more limbs with no objective loss of sensation. It may cause prolonged periods of disability. Treatment options for MMN are few. People with MMN do not usually respond to steroids or plasma exchange. […]
Pharmacological treatment for familial amyloid polyneuropathy
Abstract Background Disease‐modifying pharmacological agents for transthyretin (TTR)‐related familial amyloid polyneuropathy (FAP) have become available in the last decade, but evidence on their efficacy and safety is limited. This review focuses on disease‐modifying pharmacological treatment for TTR‐related and other FAPs, encompassing amyloid kinetic stabilisers, amyloid matrix solvents, and amyloid precursor inhibitors. Objectives To assess and […]
Pharmacological treatment for familial amyloid polyneuropathy
Abstract Background Disease‐modifying pharmacological agents for transthyretin (TTR)‐related familial amyloid polyneuropathy (FAP) have become available in the last decade, but evidence on their efficacy and safety is limited. This review focuses on disease‐modifying pharmacological treatment for TTR‐related and other FAPs, encompassing amyloid kinetic stabilisers, amyloid matrix solvents, and amyloid precursor inhibitors. Objectives To assess and […]
Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain-Barré syndrome
Abstract Background Plasma exchange and intravenous immunoglobulin, but not corticosteroids, are beneficial in Guillain‐Barré syndrome (GBS). The efficacy of other pharmacological agents is unknown. This review was first published in 2011 and previously updated in 2013, and 2016. Objectives To assess the effects of pharmacological agents other than plasma exchange, intravenous immunoglobulin and corticosteroids for […]
Interventions for ulceration and other skin changes caused by nerve damage in leprosy
Abstract Background At the end of 2016, 145 countries reported to the World Health Organization (WHO) over 173,000 new cases of leprosy worldwide. In the past 20 years, over 16 million people have been treated for leprosy globally. The condition’s main complications are injuries and ulceration caused by sensory loss from nerve damage. In this […]
Interventions for ulceration and other skin changes caused by nerve damage in leprosy
Abstract available in English Español Français Background At the end of 2016, 145 countries reported to the World Health Organization (WHO) over 173,000 new cases of leprosy worldwide. In the past 20 years, over 16 million people have been treated for leprosy globally. The condition’s main complications are injuries and ulceration caused by sensory loss […]
Genetic testing for prevention of severe drug‐induced skin rash
Abstract Background Drug‐induced skin reactions present with a range of clinical symptoms, from mild maculopapular skin rashes to potentially fatal blistering skin rashes — such as Stevens‐Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) — which may result in death. Milder reactions may be troublesome and lead to low drug compliance. The pathogenesis of these […]
Interventions for treating neuropathic pain in people with sickle cell disease
Abstract Background Pain is the hallmark of sickle cell disease (SCD) and it can be severe, frequent and unpredictable. Although nociceptive pain is more common, at times, people with SCD may have neuropathic pain. The latter can occur due to peripheral or central nerve injury. This review is focused on identifying treatment of only painful […]
Interventions for treating neuropathic pain in people with sickle cell disease
Abstract Background Pain is the hallmark of sickle cell disease (SCD) and it can be severe, frequent and unpredictable. Although nociceptive pain is more common, at times, people with SCD may have neuropathic pain. The latter can occur due to peripheral or central nerve injury. This review is focused on identifying treatment of only painful […]