Milnacipran for neuropathic pain in adults
Abstract Background Milnacipran is a serotonin–norepinephrine reuptake inhibitor (SNRI) that is sometimes used to treat chronic neuropathic pain and fibromyalgia. This is an update of an earlier review of milnacipran for neuropathic pain and fibromyalgia in adults originally published inThe Cochrane Library Issue 3, 2012. We split that review so that this one looked only […]
Milnacipran for neuropathic pain and fibromyalgia in adults
Abstract Background This is an updated version of the original Cochrane review published in Issue 3, 2012. That review considered both fibromyalgia and neuropathic pain, but the efficacy of milnacipran for neuropathic pain is now dealt with in a separate review. Milnacipran is a serotonin‐norepinephrine (noradrenaline) reuptake inhibitor (SNRI) that is licensed for the treatment […]
Treatment for inclusion body myositis
Abstract Background Inclusion body myositis (IBM) is a late-onset inflammatory muscle disease (myopathy) associated with progressive proximal and distal limb muscle atrophy and weakness. Treatment options have attempted to target inflammatory and atrophic features of this condition (for example with immunosuppressive and immunomodulating drugs, anabolic steroids, and antioxidant treatments), although as yet there is no […]
Pharmacological treatments for fatigue associated with palliative care
Abstract Background This review updates the original review, ‘Pharmacological treatments for fatigue associated with palliative care’ and also incorporates the review ‘Drug therapy for the management of cancer-related fatigue’. In healthy individuals, fatigue is a protective response to physical or mental stress, often relieved by rest. By contrast, in palliative care patients’ fatigue can be […]
Pharmacological treatment for pain in Guillain-Barré syndrome
Abstract Background Pain in Guillain-Barré syndrome (GBS) is common, yet it is often under recognised and poorly managed. In recent years, a variety of pharmacological treatment options have been investigated in clinical trials for people with GBS-associated pain. This is an updated version of the original Cochrane review published in Issue 10, 2013. Objectives To […]
Quinine for muscle cramps
Abstract Background Muscle cramps can occur anywhere and for many reasons. Quinine has been used to treat cramps of all causes. However, controversy continues about its efficacy and safety. This review was first published in 2010 and searches were updated in 2014. Objectives To assess the efficacy and safety of quinine‐based agents in treating muscle […]
Treatment for IgG and IgA paraproteinaemic neuropathy
Abstract Background Paraproteinaemic neuropathy refers to those neuropathies associated with a monoclonal gammopathy or paraprotein. The most common of these present with a chronic, predominantly sensory, symmetrical neuropathy, similar to chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) but with relatively more sensory involvement, both clinically and neurophysiologically. The optimal treatment for neuropathies associated with IgG and IgA […]
Surgery for nonarteritic anterior ischemic optic neuropathy
Abstract Background Nonarteritic anterior ischemic optic neuropathy (NAION) is characterized by sudden and painless loss of vision in the eye, accompanied by pallid swelling of the optic disc. Its etiology is unknown and no medical therapy has been proven effective in treating this condition. Optic nerve decompression surgery, a proposed treatment for NAION, involves making […]
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy
Abstract Background Multifocal motor neuropathy (MMN) is characterised by progressive, predominantly distal, asymmetrical limb weakness and usually multiple partial motor nerve conduction blocks. Intravenous immunoglobulin (IVIg) is beneficial but the role of immunosuppressive agents is uncertain. This is an update of a review first published in 2002 and previously updated in 2003, 2005, 2008 and […]
Zonisamide for neuropathic pain in adults
Abstract Background Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. The efficacy of zonisamide for the relief of neuropathic pain has not previously been reviewed. Objectives To assess the analgesic efficacy and associated adverse events of zonisamide for chronic neuropathic pain in […]