Clonazepam for neuropathic pain and fibromyalgia in adults
Abstract Background Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. Clonazepam, a benzodiazepine, is an established antiepileptic drug, but its place in the treatment of neuropathic pain is unclear. Objectives To assess the analgesic efficacy and adverse effects of the antiepileptic drug […]
Treatment for mitochondrial disorders
Abstract Background Mitochondrial respiratory chain disorders are the most prevalent group of inherited neurometabolic diseases. They present with central and peripheral neurological features usually in association with other organ involvement including the eye, the heart, the liver, and kidneys, diabetes mellitus and sensorineural deafness. Current treatment is largely supportive and the disorders progress relentlessly causing […]
Treatment for cramps in amyotrophic lateral sclerosis /motor neuron disease
Abstract Background Cramps are painful, involuntary muscle contractions. They commonly affect people with amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) at all stages of the disease. To date, the treatment of muscle cramps in ALS has been largely empirical without any evidence from randomised controlled trials. Objectives To systematically assess the effect of interventions on muscle […]
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
Abstract Background Riluzole is approved for the treatment of amyotrophic lateral sclerosis in most countries. Questions persist about its clinical utility because of high cost and modest efficacy. Objectives To examine the efficacy of riluzole in prolonging survival and in delaying the use of surrogates (tracheostomy and mechanical ventilation) to sustain survival, and to assess […]
Cold-water immersion (cryotherapy) for preventing and treating muscle soreness after exercise
Abstract Background Many strategies are in use with the intention of preventing or minimising delayed onset muscle soreness and fatigue after exercise. Cold-water immersion, in water temperatures of less than 15°C, is currently one of the most popular interventional strategies used after exercise. Objectives To determine the effects of cold-water immersion in the management of […]
Hyperbaric oxygen therapy for Bell’s palsy
Abstract Background Bell’s palsy is an idiopathic, acute unilateral facial weakness that evolves rapidly and is maximal within two days. Moderate ear discomfort, sensitivity to sound and reduced tearing may occur. Objectives To assess the effects of hyperbaric oxygen therapy on recovery of facial function in adults with moderate to severe Bell’s palsy. Search methods […]
Lacosamide for neuropathic pain and fibromyalgia in adults
Abstract Background Antiepileptic drugs have been used in pain management since the 1960s; some seem to be especially useful for neuropathic pain. Lacosamide is an antiepileptic drug that has recently been investigated for neuropathic pain relief, although it failed to get approval for painful diabetic peripheral neuropathy from either the Food and Drug Administration or […]
Treatment for spasticity in amyotrophic lateral sclerosis/motor neuron disease
Abstract Background Spasticity commonly affects patients with motor neuron disease. It is likely to contribute to worsening muscle dysfunction, increased difficulty with activities of daily living and deteriorating quality of life. This is an update of a review first published in 2003 and previously updated in 2005 and 2008. Objectives The objective of this review […]
Ergonomic positioning or equipment for treating carpal tunnel syndrome
Abstract Background Non-surgical treatment, including ergonomic positioning or equipment, are sometimes offered to people experiencing mild to moderate symptoms from carpal tunnel syndrome (CTS). The effectiveness and duration of benefit from ergonomic positioning or equipment interventions for treating CTS are unknown. Objectives To assess the effects of ergonomic positioning or equipment compared with no treatment, […]
Non-drug therapies for lower limb muscle cramps
Abstract Background About one in every three adults are affected by lower limb muscle cramps. For some people, these cramps reduce quality of life, quality of sleep and participation in activities of daily living. Many interventions are available for lower limb cramps, but some are controversial, no treatment guidelines exist, and often people experience no […]