Creatine for treating muscle disorders
Abstract Background Progressive muscle weakness is a main symptom of most hereditary and acquired muscle diseases. Creatine improves muscle performance in healthy individuals. This is an update of our 2007 Cochrane review that evaluated creatine treatment in muscle disorders. Previous updates were in 2009 and 2011. Objectives To evaluate the efficacy of creatine compared to […]
Drug therapy for pain in amyotrophic lateral sclerosis or motor neuron disease
Abstract Background Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is the most common neurodegenerative disorder of the motor system in adults. Pain in ALS is a frequent symptom especially in the later stages of disease and can have a pronounced influence on quality of life and suffering. Treatment of pain therefore […]
Therapeutic exercise for people with amyotrophic lateral sclerosis or motor neuron disease
Abstract Background Despite the high incidence of muscle weakness in individuals with amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND), the effects of exercise in this population are not well understood. This is an update of a review first published in 2008. Objectives To systematically review randomised and quasi-randomised studies of exercise for people […]
Repetitive transcranial magnetic stimulation for the treatment of amyotrophic lateral sclerosis or motor neuron disease
Abstract Background Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a progressive neurodegenerative disease without effective therapies. Several studies have suggested that repetitive transcranial magnetic stimulation (rTMS) may have positive benefit in ALS. However, the efficacy and safety of this therapy remain uncertain. This is the first update of a review […]
Therapeutic ultrasound for carpal tunnel syndrome
Abstract Background Therapeutic ultrasound may be offered to people experiencing mild to moderate symptoms of carpal tunnel syndrome (CTS). The effectiveness and duration of benefit of this non-surgical intervention remain unclear. Objectives To review the effects of therapeutic ultrasound compared with no treatment, placebo or another non-surgical intervention in people with CTS. Search methods On […]
Mechanical ventilation for amyotrophic lateral sclerosis/motor neuron disease
Abstract Background Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is a fatal neurodegenerative disease. Neuromuscular respiratory failure is the most common cause of death, which usually occurs within two to five years of the disease onset. Supporting respiratory function with mechanical ventilation may improve survival and quality of life. This is the […]
Corticosteroids for preventing postherpetic neuralgia
Abstract Background Postherpetic neuralgia is a common, serious painful complication of herpes zoster. Corticosteroids are anti-inflammatory and might be beneficial. This is an update of a review first published in 2008 and previously updated in 2010. Objectives To examine the efficacy of corticosteroids in preventing postherpetic neuralgia. Search methods We updated the searches for randomised […]
Treatment for meralgia paraesthetica
Abstract Background Meralgia paraesthetica is a clinical syndrome for which a number of treatments are in common use, including conservative measures, injection of corticosteroid with local anaesthetic and surgery. We aimed to examine the evidence for the relative efficacy of these interventions. This review was first published in 2008. Searches were updated in 2010 and […]
Intravenous immunoglobulin for myasthenia gravis
Abstract Background Myasthenia gravis is an autoimmune disease in which autoantibodies interfere with neuromuscular transmission. As with other autoimmune diseases, people with myasthenia gravis would be expected to benefit from intravenous immunoglobulin (IVIg). This is an update of a review first published in 2003 and last updated in 2007. Objectives To examine the efficacy of […]
Medical and surgical treatment for ocular myasthenia
Abstract Background Approximately 50% of people with myasthenia gravis present with purely ocular symptoms, so called ocular myasthenia. Of these between 50% to 60% develop generalized disease, most within two years. Their management is controversial. This is an update of a review first published in 2006 and previously updated in 2008 and 2010. Objectives To […]