Helmets for preventing head and facial injuries in bicyclists
Abstract Background Each year, in the United States, approximately 900 persons die from injuries due to bicycle crashes and over 500,000 persons are treated in emergency departments. Head injury is by far the greatest risk posed to bicyclists, comprising one-third of emergency department visits, two-thirds of hospital admissions, and three-fourths of deaths. Facial injuries to […]
School-based driver education for the prevention of traffic crashes
Abstract Background In the UK, drivers aged 17 to 21 years make up 7% of licence holders but 13% of drivers involved in road traffic crashes resulting in injury. As in many countries, the UK government has proposed to tackle this problem with driver education programmes in schools and colleges. However, there is a concern […]
Aminosteroids for acute traumatic brain injury
Abstract Background Traumatic brain injury is a leading cause of premature death and disability. Post-traumatic membrane lipid peroxidation has been proposed as one mechanism leading to secondary brain damage following head injury. Aminosteroids have been shown to inhibit lipid peroxidation in laboratory animals and have the potential to improve outcome following head injury. Objectives To […]
Calcium channel blockers for acute traumatic brain injury
Abstract Background Acute traumatic brain injury is a major cause of death and disability. Calcium channel blockers (calcium antagonists) have been used in an attempt to prevent cerebral vasospasm after injury, maintain blood flow to the brain, and so prevent further damage. Objectives To estimate the effects of calcium channel blockers in patients with acute […]
Post-licence driver education for the prevention of road traffic crashes
Abstract Background Worldwide, each year over a million people are killed and some ten million people are permanently disabled in road traffic crashes. Post-licence driver education is used by many as a strategy to reduce traffic crashes. However, the effectiveness of post-licence driver education has yet to be ascertained. Objectives To quantify the effectiveness of […]
Excitatory amino acid inhibitors for traumatic brain injury
Abstract Background Glutamate is the principal excitatory neurotransmitter in the brain. Injury to the brain can cause an ionic imbalance in cerebral tissue, creating an excitotoxic cascade involving glutamate and other excitatory amino acids, that leads to neuronal death in the tissue surrounding the original injury site. Research has centred around inhibiting this increase in […]
Sensory stimulation for brain injured individuals in coma or vegetative state
Abstract Background Coma and vegetative state follow traumatic brain injury in about one out of eight patients, and in patients with non traumatic injury the prognosis is worse. The use of sensory stimulation for coma and vegetative state has gained popularity during the 1980’s but beliefs and opinions about its effectiveness vary substantially among health […]
Medical anti-shock trousers (pneumatic anti-shock garments) for circulatory support in patients with trauma
Abstract Background Medical antishock trousers (MAST) have been used to increase venous return to the heart until definitive care could be given. This, combined with compression of blood vessels, is believed to cause the movement of blood from the lower body to the brain, heart and lungs. However, the equipment is expensive, and may have […]
Hyperventilation therapy in acute traumatic brain injury
Abstract Background Because hyperventilation is often associated with a rapid fall in intracranial pressure, it has been assumed to be effective in the treatment of severe head injury. Hyperventilation reduces raised intracranial pressure by causing cerebral vasoconstriction and a reduction in cerebral blood flow. Whether or not reduced cerebral blood flow improves neurological outcome is, […]