Early versus delayed mobilisation for aneurysmal subarachnoid haemorrhage
Abstract Background Rebleeding is an important cause of death and disability in patients with aneurysmal subarachnoid haemorrhage (SAH). In order to prevent rebleeding, the preferred strategy is aneurysm ablation (removal) as early as possible. However, in clinical practice some patients are not suitable for surgical treatment, or prefer conservative treatments. In some countries, therefore, total […]
Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews
Abstract Background There is currently no strong consensus regarding the optimal management of complex regional pain syndrome although a multitude of interventions have been described and are commonly used. Objectives To summarise the evidence from Cochrane and non-Cochrane systematic reviews of the effectiveness of any therapeutic intervention used to reduce pain, disability or both in […]
Cognitive rehabilitation for executive dysfunction in adults with stroke or other adult non-progressive acquired brain damage
Abstract Background Executive functions are the controlling mechanisms of the brain and include the processes of planning, initiation, organisation, inhibition, problem solving, self monitoring and error correction. They are essential for goal-oriented behaviour and responding to new and novel situations. A high number of people with acquired brain injury, including around 75% of stroke survivors, […]
Cholesterol-reducing agents for aneurysmal subarachnoid haemorrhage
Abstract Background Cerebral vasospasm and related delayed ischaemic deficits (DIDs) occur in about 17% to 40% of patients with aneurysmal subarachnoid haemorrhage (SAH) and lead to a poor outcome. Cholesterol-reducing agents might improve unfavourable outcomes. Objectives To assess the effects of cholesterol-reducing agents for improving outcomes in patients with aneurysmal SAH. Search methods We searched […]
Sonothrombolysis for acute ischaemic stroke
Abstract Background Sonothrombolysis is a promising but unproven tool for treating acute ischaemic stroke. There is an ongoing debate about the efficacy, safety, technical aspects of ultrasound administration and the possible potentiating effect of microbubbles. Objectives To assess the effectiveness and safety of sonothrombolysis in patients with acute ischaemic stroke. Search methods We searched the […]
Piracetam for acute ischaemic stroke
Abstract Background Piracetam has neuroprotective and antithrombotic effects that may help to reduce death and disability in people with acute stroke. This is an update of a Cochrane Review first published in 1999, and previously updated in 2006 and 2009. Objectives To assess the effects of piracetam in acute, presumed ischaemic stroke. Search methods We […]
Endothelin receptor antagonists for subarachnoid hemorrhage
Abstract Background A subarachnoid hemorrhage (SAH) is a serious and potentially life-threatening condition where blood leaks out of blood vessels over the surface of the brain. Delayed ischemic neurological deficit (DIND) and the related feature of vasospasm, where patients experience a delayed deterioration, have long been recognized as the leading potentially treatable cause of death […]
Vitamin K antagonists versus antiplatelet therapy after transient ischaemic attack or minor ischaemic stroke of presumed arterial origin
Abstract Background People who have had a transient ischaemic attack (TIA) or non-disabling ischaemic stroke have an annual risk of major vascular events of between 4% and 11%. Aspirin reduces this risk by 20% at most. Secondary prevention trials after myocardial infarction indicate that treatment with vitamin K antagonists is associated with a risk reduction […]
Inspiratory muscle training for the recovery of function after stroke
Abstract Background Inspiratory muscle weakness has been observed in patients with stroke. Inspiratory muscle training is an intervention that has shown possible effects for functional recovery of patients with stroke. Objectives To investigate the effect and safety of inspiratory muscle training for improving activities of daily living, respiratory muscle function, quality of life and cardiorespiratory […]
Home-based therapy programmes for upper limb functional recovery following stroke
Abstract Background With an increased focus on home-based stroke services and the undertaking of programmes, targeted at upper limb recovery within clinical practice, a systematic review of home-based therapy programmes for individuals with upper limb impairment following stroke was required. Objectives To determine the effects of home-based therapy programmes for upper limb recovery in patients […]