Surgical decompression for cerebral oedema in acute ischaemic stroke
Abstract Background Large cerebral infarction has a high case fatality. Despite the use of conventional medical treatments such as hyperventilation, mannitol, diuretics, corticosteroids and barbiturates, the outcome of this condition remains poor. Decompressive surgery to relieve intracranial pressure is performed in some cases, although evidence of any clinical benefits has not been available until recently. […]
Edaravone for acute ischaemic stroke
Abstract Background Neuroprotection is a promising therapeutic strategy for the treatment of acute ischaemic stroke. Edaravone is a neuroprotective agent that has been widely used in China, and several studies have suggested that it may be beneficial in acute ischaemic stroke. Objectives To assess the efficacy and safety of edaravone for acute ischaemic stroke. Search […]
Corticosteroids for acute ischaemic stroke
Abstract Background The majority of strokes are due to cerebral infarction. Ischaemic cerebral tissue tends to develop cytotoxic oedema which, if the blood-brain barrier is disrupted, may be followed by vasogenic oedema. Large infarcts can develop life-threatening massive oedema. Early treatment with corticosteroids could theoretically help reduce both cytotoxic and vasogenic oedema and so improve […]
Statins for acute ischemic stroke
Abstract Background Statins have been claimed to be effective in the acute phase of ischemic stroke. The potential positive actions of statins during an acute cerebrovascular ischemic event are two-fold: a neuroprotective effect, limiting damage and improving recovery; and a preventative effect on early recurrence. Objectives To quantify the potential benefits and harms of statins […]
Percutaneous vascular interventions for acute ischaemic stroke
Abstract Background Most disabling strokes are due to blockage of a large artery in the brain by a blood clot. Prompt removal of the clot with intra-arterial thrombolytic drugs or mechanical devices, or both, can restore blood flow before major brain damage has occurred, leading to improved recovery. However, these so-called percutaneous vascular interventions can […]
Acanthopanax for acute ischaemic stroke
Abstract Background Acute ischaemic stroke is a common cause of death and disability. A number of studies published in China have shown that acanthopanax is beneficial for acute ischaemic stroke. Objectives To assess the efficacy and safety of acanthopanax in patients with acute ischaemic stroke. Search methods We searched the Cochrane Stroke Group Trials Register […]
Anticoagulants for preventing recurrence following presumed non-cardioembolic ischaemic stroke or transient ischaemic attack
Abstract Background After a first ischaemic stroke, further vascular events due to thromboembolism are common and often fatal. Anticoagulants could potentially reduce the risk of such events, but any benefits could be offset by an increased risk of fatal or disabling haemorrhages. Objectives To assess the effect of prolonged anticoagulant therapy compared with placebo or […]
Dengzhanhua preparations for acute cerebral infarction
Abstract Background Dengzhanhua preparations are widely used in China. Many controlled trials have been undertaken to investigate the efficacy of dengzhanhua preparations in the treatment of acute cerebral infarction. Objectives To assess whether dengzhanhua preparations are effective and safe at improving outcomes in patients with acute cerebral infarction. Search methods We searched the Cochrane Stroke […]
Chuanxiong-type preparations for acute ischemic stroke
Abstract Background Stroke, 88% of which are ischemic, is a common cause of death and disability all over the world. Chuanxiong has been reported to be beneficial in treating stroke. However, the strength of evidence to support its use is unclear. Objectives To assess the safety and efficacy of chuanxiong for acute ischemic stroke. Search […]
Sanchi for acute ischaemic stroke
Abstract Background Currently very few drugs are supported for routine use for acute ischaemic stroke. Sanchi is one of the most widely used herbal medicines for ischaemic stroke in China. Objectives To assess the effectiveness and safety of sanchi in the treatment of acute ischaemic stroke. Search methods We searched the Cochrane Stroke Group Trials […]