Gamma-hydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses
Abstract Background Chronic excessive alcohol consumption may lead to dependence, and to alcohol withdrawal syndrome (AWS) in case of abrupt drinking cessation. Gamma-hydroxybutyric acid (GHB) can prevent and suppress withdrawal symptoms, and improve the medium-term abstinence rate. However, clear estimates of its beneficial and harmful effects have not been yet established. Objectives To evaluate the […]
Psychotropic analgesic nitrous oxide for alcoholic withdrawal states
Abstract Background Alcoholism is a global problem with 5-10% of the world’s population demonstrating alcohol-related diseases. One of the most severe consequences of alcohol dependence is the withdrawal syndrome, for which benzodiazepines are the most popular current treatment. An alternative method to benzodiazepine employs psychotropic analgesic nitrous oxide (PAN). Objectives To assess the effects of […]
S-adenosyl-L-methionine for alcoholic liver diseases
Abstract Background Alcohol is a major cause of liver disease and disrupts methionine and oxidative balances. S-adenosyl-L-methionine (SAMe) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione, the main cellular antioxidant. Randomised clinical trials have addressed the question whether SAMe may benefit patients with alcoholic liver diseases. […]